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  • Title: Prenatal cocaine exposure: increased striatal dopamine transporter binding in offspring at 3 and 6 months of age.
    Author: Koff JM, Miller LG.
    Journal: Brain Res Bull; 1994; 33(2):223-4. PubMed ID: 8275343.
    Abstract:
    Prior studies indicate that prenatal cocaine exposure can alter dopamine transporter binding in mature mice. To determine the persistence of these effects, pregnant mice were treated with cocaine, 10 mg/kg/d, during days 13 to 20 of gestation and dopamine transporter binding was evaluated in offspring at 3 and 6 months of age. In contrast to prior studies, binding in striatum was significantly increased at both time points in cocaine-exposed mice compared to controls.
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