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  • Title: [A pathological analysis of 51 cases of renal osteodystrophy].
    Author: Yu YF, Hu YX, Zhu P.
    Journal: Zhonghua Nei Ke Za Zhi; 1993 Jul; 32(7):448-50. PubMed ID: 8275821.
    Abstract:
    Renal osteodystrophy is a metabolic bone disease of chronic renal failure. The long-standing alterations in mineral metabolism generated by renal failure have a profound effect on the skeleton and induce severe systemic metabolic bone disease. Iliac crest biopsy was performed in 51 patients of chronic renal failure and examined with microscopy. The histological bone changes are characterized by ostitis fibrosa, increased resorption of bone and number of osteoclasts, increased osteoid volume (osteoblastic osteoid and acellular osteoid), active remodelling of bone and aluminum deposition in bone. According to the histological appearance, advanced renal bone disease can be subdivided into three major histological groups: secondly hyperparathyroid bone disease (high turnover uremic osteodystrophy), osteomalacia (low turnover uremic osteodystrophy) and mixed uremic osteodystrophy consisting of mild to moderate hyperparathyroid bone disease and defective mineralization. Aluminum-related bone changes can be seen in varying degrees in all these groups. Even though these groups do not fully represent separate entities and transformation from one form to another can occur, it is essential to distinguish them since therapy can be tailored according to the predominant histologic findings.
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