These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Characterization of iopromide liposomes.
    Author: Krause W, Leike J, Sachse A, Schuhmann-Giampieri G.
    Journal: Invest Radiol; 1993 Nov; 28(11):1028-32. PubMed ID: 8276573.
    Abstract:
    RATIONALE AND OBJECTIVES: Iopromide-carrying liposomes were prepared and were characterized pharmaceutically and biologically. METHODS: The liposomes were prepared by the ethanol evaporation method and were characterized by quasi-elastic light scattering (size) and equilibrium dialysis (encapsulation efficiency and stability). Acute and subchronic toxicity was tested in mice and/or rats and cardiovascular tolerance in rabbits. Pharmacokinetic parameters were determined in rats. Computed tomography (CT) imaging efficiency was obtained from rat and rabbit studies. RESULTS: The mean diameter was 0.5 +/- 0.1 micron and the encapsulation efficiency ranged between 30% and 40%. The liposomes were stable in human and rabbit plasma for approximately 24 hours. The LD50 in mouse and rat was approximately 3 g iodine/kg. In a subchronic toxicity study in rats with six doses of 1 g iodine/kg given every three days, no adverse effects were observed. The pharmacokinetics in rats were dose-dependent. Increasing the dose resulted in lower total clearance, and longer terminal half-life. Elimination of iodine was complete and the main route of excretion was via the kidneys. A clinically relevant computed tomography enhancement of the liver was reached after approximately 200 mg iodine/kg in rats and 150 mg iodine/kg in rabbits. CONCLUSIONS: The iopromide-carrying liposomes were well tolerated in animal studies and seemed to be suitable for the imaging of the liver.
    [Abstract] [Full Text] [Related] [New Search]