These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antibodies to skeletal muscle in myasthenia gravis. Part 1. Diagnostic value for the detection of thymoma.
    Author: Kuks JB, Limburg PC, Horst G, Dijksterhuis J, Oosterhuis HJ.
    Journal: J Neurol Sci; 1993 Nov; 119(2):183-8. PubMed ID: 8277333.
    Abstract:
    The role of anti-muscle antibodies (AMA) in the diagnosis of thymoma in patients with myasthenia gravis (MG) is evaluated. We compared ELISA and Western blot assay for antibodies to citric acid muscle extract (a-CAE) with an immunofluorescence assay (IF). Sera from 234 selected MG patients and 123 controls were tested. There was no essential difference between ELISA and IF. Western blot was superior in young onset patients but less useful in patients with an onset beyond the age of 40 years. Unusually high post-test probabilities were found by our patient selection criteria which seem most realistic for clinical practice. Western blot revealed no differences in specificity of AMA in thymoma and non-thymoma patients irrespective of age at onset of disease.
    [Abstract] [Full Text] [Related] [New Search]