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  • Title: Reactions of cyanomethylbenzimidazoles. Part III. Reaction of cyanomethylbenzimidazoles with isocyanates and isothiocyanates.
    Author: Milczarska B, Sawlewicz J, Manowska W.
    Journal: Pol J Pharmacol Pharm; 1976; 28(5):521-8. PubMed ID: 827741.
    Abstract:
    In the reaction of 2-cyanomethylbenzmidazole and their 1- and 5-methyl derivatives with aromatic isocyanates and isothiocyanates, 23 N-arylamides resp. thioamides of benzimidazolyl-2-alpha-cyanoacetic acid were obtained. The structure of the newly compounds (Table 1) was confirmed by NMR and IR spectra. Some of these shown moderate tuberculostatic activity in vitro.
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