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  • Title: Cyclic AMP and cyclic GMP in epidermal physiology and pathophysiology.
    Author: Voorhees JJ, Duell EA, Creehan P, Stawiski M, Harrell ER.
    Journal: Curr Probl Dermatol; 1976; 6():107-53. PubMed ID: 8278.
    Abstract:
    The second messengers cyclic AMP and cyclic GMP in several organs appear to coordinate those molecular events which are responsible for specialized organ function. As a result of balanced cell proliferation and specialization, epidermis functions by terminal specialization which provides a barrier between man and environment. Since the epidermal component of psoriasis is a classic example of deranged epidermal homeostasis, which has a low level of cyclic AMP and a high level of cyclic GMP, it seems reasonable that rebalancing these cyclic nucleotides might ultimately be a safe and effective therapy for psoriasis and other proliferative skin diseases.
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