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  • Title: [Treatment of 10 cases of symptomatic Paget's disease with etidronate (EHDP)].
    Author: Jung A, Mermillod B, Schenk R, Courvoisier B, Burkhardt P, Epiney J, Fleisch.
    Journal: Schweiz Med Wochenschr; 1976 Nov 27; 106(48):1667-73. PubMed ID: 827810.
    Abstract:
    10 patients with active symptomatic Paget's disease of bone have been treated for 6 months with disodium etidronate (EHDP) at a dose of 20 mg/kg/day. A statistically significant fall in the serum levels of alkaline phosphatase and urinary hydroxyproline was observed. However, only 2 patients experienced a significant reduction of bone pain. 6 patients were partially improved and 2 patients showed no change. Iliac crest biopsies after treatment demonstrated dimunution of the abnormal structure of the pagetic bone, but also a considerable increase in unmineralized osteoid borders. The future potentialities for treatment of Paget's disease are discussed.
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