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  • Title: [A case of myocardiopathy with hypothiaminemia exacerbated by imiparmine].
    Author: Gaudeau S, Derrida JP, Tillement JP, Vernant P.
    Journal: Arch Mal Coeur Vaiss; 1976 Oct; 69(10):1083-8. PubMed ID: 828003.
    Abstract:
    The authors report a case of a lady of 45 years of age who presented with a cardiomyopathy with hypothiaminaemia which had been made considerably worse by treatment with imipramine. Once treatment with the antidepressant was stopped, her condition returned to its previous status. The very high plasma imipramine level recorded in his case is undoubtedly the reason for the cardiac toxicity. The mechanism and role of hypothiaminaemia have not far been explained logically.
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