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  • Title: Apolipoprotein B mRNA editing in vitro is a zinc-dependent process.
    Author: Barnes C, Smith HC.
    Journal: Biochem Biophys Res Commun; 1993 Dec 30; 197(3):1410-4. PubMed ID: 8280158.
    Abstract:
    Apolipoprotein B mRNA editing involves the conversion of a cytidine at nucleotide 6666 to a uridine, thereby creating a translational stop codon from a glutamine codon. Recent evidence suggest that a cytidine deaminase is responsible for catalyzing the C to U conversion. All known nucleotide deaminases require zinc as part of their catalytic domain. Utilizing the selective chelator for zinc, 1,10-penanthroline, we demonstrate that in vitro editing activity in rat liver extracts is zinc dependent. These data, taken together with recent reports, strongly support a role for a cytidine deaminase and nucleotide conversion as the catalytic mechanism for apoB mRNA editing.
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