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  • Title: 5' nucleotidase activity in leukaemic lymphocytes.
    Author: Kramers MT, Catovsky D, Foa R, Cherchi M, Galton DA.
    Journal: Biomedicine; 1976 Dec 30; 25(10):363-5. PubMed ID: 828064.
    Abstract:
    The enzyme 5' nucleotidase (E.C.3.1.3.5.) is present in lymphocytes isolated from the blood of normal subjects. The activity was extremely low in lymphocytes from 17 patients with B lymphocytic leukaemias. Removal of normal lymphocytes from the B-cell leukaemic samples decreased further the enzyme activity. Moderately low values were observed in three cases of T-ALL and in the cells from a case of Sézary syndrome. In contrast, normal or high values were observed in three cases of ALL in which T and B markers were not demonstrable and in two of T-CLL. No differences were observed in partially purified subpopulations of normal B and T cells.
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