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  • Title: Evidence that the F2-isoprostane, 8-epi-prostaglandin F2 alpha, is formed in vivo.
    Author: Morrow JD, Minton TA, Badr KF, Roberts LJ.
    Journal: Biochim Biophys Acta; 1994 Jan 03; 1210(2):244-8. PubMed ID: 8280777.
    Abstract:
    F2-isoprostanes are prostaglandin (PG)F2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid. One F2-isoprostane whose formation should be favored is 8-epi-PGF2 alpha. 8-Epi-PGF2 alpha has been shown to exert potent bioactivity but proof that it is formed in vivo is lacking. Evidence is now presented suggesting that 8-epi-PGF2 alpha is, in fact, formed in vivo by demonstrating that an endogenous F2-isoprostane with a retention time on capillary GC identical with that of 8-epi-PGF2 alpha co-chromatographs through four high resolving HPLC purification procedures with authentic radiolabelled 8-epi-PGF2 alpha.
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