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  • Title: Lymphocyte surface immunoglobulins: detection, characterization, and occurrence in disease of the lymphoid system.
    Author: Warr GW, Marchalonis JJ.
    Journal: CRC Crit Rev Clin Lab Sci; 1976; 7(2):185-226. PubMed ID: 828087.
    Abstract:
    Surface immunoglobulins (Igs) of lymphocytes are of considerable interest because these molecules probably function as receptors for antigen, and knowledge of their molecular properties should provide information on the mechanisms of immune differentiation. The density and types of surface Ig on a cell provide markers useful in indicating the class of a lymphocyte and its stage of maturity. Moreover, knowledge of the specificities of the surface Ig of neoplastic lymphocytes might suggest the nature of agents involved in the generation of the disease. Two broad classes of lymphocytes, bone marrow-derived lymphocytes (B cells) active in antibody secretion, and thymus-derived lymphocytes (T cells) which mediate cellular immune reactions, and their subpopulations must be considered with reference to the nature, origin, and function of their surface immunoglobulin. This article analyzes direct and indirect methods for the demonstration of surface Igs and describes certain physicochemical properties of isolated surface Ig molecules. Roles of these surface molecules in recognition of antigen, initiation of all differentiation, and cooperation among lymphocytes and accessory cells are discussed.
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