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  • Title: Molecular conformation of patellamide A, a cytotoxic cyclic peptide from the ascidian Lissoclinum patella, by X-ray crystal analysis.
    Author: In Y, Doi M, Inoue M, Ishida T, Hamada Y, Shioiri T.
    Journal: Chem Pharm Bull (Tokyo); 1993 Oct; 41(10):1686-90. PubMed ID: 8281568.
    Abstract:
    As part of a series of investigations into the conformational stability of a C2-symmetric or related cyclic peptide isolated from the ascidian Lissoclinum patella, the molecular conformation of patellamide A, the chemical structure of which deviates slightly for C2-symmetry, was determined by X-ray crystal analysis. Patellamide A took on a saddle-shaped rectangular form and wrapped around the water and methanol solvents. This conformation which is very similar to that of C2-symmetric ascidiacyclamide would be proposed as a possible candidate for biologically "active" conformation.
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