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  • Title: Dilated cardiomyopathy and myocarditis in Kenya: an endomyocardial biopsy study.
    Author: Sanderson JE, Olsen EG, Gatei D.
    Journal: Int J Cardiol; 1993 Sep; 41(2):157-63. PubMed ID: 8282440.
    Abstract:
    We have studied, by light and electron microscopy, left ventricular endomyocardial biopsy specimens from 18 African patients (14 men) with idiopathic dilated cardiomyopathy in Nairobi. Nine patients (50%) had evidence of healing myocarditis, that is the presence of a mild inflammatory cell infiltration within the myocardium. Interstitial fibrosis was prominent in five patients (28%) and in all 18 specimens there were hypertrophied muscle fibres. Therefore, half of the patients with idiopathic dilated cardiomyopathy had histological signs of a previous myocarditis. There was no serological evidence of a previous or recent coxsackie infection or any other common viral infections. It seems probable that the myocarditis was due to an inappropriate immunological reaction to myocardial muscle.
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