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  • Title: [Effect of enalapril on left ventricular hypertrophy and left ventricular function in patients with hypertension].
    Author: Kakinoki S, Takechi S, Hashimoto M, Sakuma I, Nomura A, Kitabatake A, Yasuda H.
    Journal: Kokyu To Junkan; 1993 Dec; 41(12):1185-9. PubMed ID: 8284542.
    Abstract:
    The aim of this study was to study the effect of enalapril (E) on left ventricular (LV) mass, LV function and blood renin-angiotensin (RA) in patients with hypertension. Sixteen hypertensives were included in this study (WHO I 8, WHO II 8, 49.5 +/- 10.5 yrs). They were examined for blood pressure and heart rate. Chest X-ray film, echocardiography (echo), X-ray computed tomography (CT) and RA before and after about 6 months of E administration were studied. The LV mass was calculated by CT. The LV function was measured by echo. RAS was unchanged during this study. LV mass was significantly reduced after E (121.4 +/- 25.6 vs 104.6 +/- 13.7 g/cm2). The LV systolic function was unchanged after E, but LV diastolic function improved. It was shown that the long-term administration of E improves LV hypertrophy and LV diastolic function without any change of RAS.
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