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  • Title: Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice.
    Author: Fujimori Y, Nakamura T, Shimizu K, Yamamuro T, Wanaka K, Okamoto S, Katsuura Y.
    Journal: Agents Actions; 1993 May; 39(1-2):42-8. PubMed ID: 8285139.
    Abstract:
    A study was conducted to evaluate the effects of a new, highly selective plasma kallikrein inhibitor, PKSI-527, on collagen-induced arthritis (CIA) in mice. PKSI-527 or indomethacin was administered daily intraperitoneally from day 20 postimmunization. Clinical evaluation was performed, and two of the components of the kallikrein-kinin system, high-molecular-weight (HMW) kininogen and plasma prekallikrein, were assayed. PKSI-527, as well as indomethacin, reduced the severity of arthritis significantly. PKSI-527, but not indomethacin, restored consumed components of the kallikrein-kinin system. These results suggest that PKSI-527 suppresses CIA by modifying the kallikrein-kinin system and PKSI-527 as a synthetic plasma kallikrein inhibitor would be a valuable tool to study the mechanism of inflammation of arthritic diseases.
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