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  • Title: Herpes simplex type 2 in a patient with Mollaret's meningitis: demonstration by polymerase chain reaction.
    Author: Cohen BA, Rowley AH, Long CM.
    Journal: Ann Neurol; 1994 Jan; 35(1):112-6. PubMed ID: 8285581.
    Abstract:
    We describe a patient with recurrent self-limited aseptic meningitis meeting the criteria for Mollaret's syndrome, in whom extensive serological investigation and cerebrospinal fluid analysis failed to reveal a specific cause. Using polymerase chain reaction techniques to amplify herpes simplex viral DNA, we were able to identify the presence of herpes simplex virus type 2 in the cerebrospinal fluid. The duration of clinical illness may have been shortened by treatment with intravenous acyclovir. We suggest that herpes simplex virus may be a more common cause of aseptic meningitis than has been demonstrated by current commonly available serological and culture techniques.
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