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  • Title: Circadian rhythms in polyamine excretion by rats bearing an immunocytoma.
    Author: Halberg F, Gehrke CW, Zinneman HH, Kuo K, Nelson WL, Dubey DP, Cadotte LM, Haus E, Scheving LE, Good RA, Rosenberg A, Soong L, Bazin H, Abdel-Monem MM.
    Journal: Chronobiologia; 1976; 3(4):309-22. PubMed ID: 828877.
    Abstract:
    Large-amplitude circadian rhythms were observed in the urinary excretion of polyamines by rats bearing an immunocytoma. Control animals excreted polyamines at a lower rate but also with marked circadian variation. In confirmation of earlier observations, light-chain excretion by the tumor-bearing rats also exhibited a circadian rhythm, superimposed on an increasing trend. The potential of these rhythms as markers for the chronotherapy of cancer is noted.
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