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  • Title: Significance of pH on differentiation of human erythroid cell lines.
    Author: Endo T, Ishibashi Y, Okana H, Fukumaki Y.
    Journal: Leuk Res; 1994 Jan; 18(1):49-54. PubMed ID: 8289466.
    Abstract:
    As physiological factors and compounds, BSA and/or higher pH of the culture medium could induce the erythroid differentiation of cells. Optimum pH values of the culture medium for higher spontaneous differentiation of KU-812 and K562 cells after 7 days cultivation were 7.5 and 7.6, respectively. The synergistic effects on the differentiation were observed by exposure to hemin under the higher pH condition. In the presence of BSA, 25% of KU-812 and 40% of K562 cells became benzidine positive. Synergistic effects of BSA and the higher pH of the medium were also observed.
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