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  • Title: Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors in dogs and humans.
    Author: Cheng H, Sutton SC, Pipkin JD, Zentner GM, Rogers JD, Schwartz JI, Mitchel YB, Grasing K, Schwartz MS, Amin RD.
    Journal: Pharm Res; 1993 Nov; 10(11):1683-7. PubMed ID: 8290485.
    Abstract:
    Seven sustained/controlled-release dosage forms were designed for gastrointestinal delivery of lovastatin or simvastatin, two potent HMG-CoA reductase inhibitors for the treatment of hypercholesterolemia. The in vivo performance of these formulations was evaluated in dogs and healthy volunteers in terms of the cholesterol lowering efficacy and/or systemic concentrations of HMG-CoA reductase inhibitors. Results from the present and previous studies suggest that, through the controlled release of HMG-CoA reductase inhibitors, sustained lower plasma concentrations of HMG-CoA reductase inhibitors may result in an equal or better therapeutic efficacy.
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