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  • Title: Bioactive glass versus hydroxylapatite in reconstruction of osteochondral defects in the rabbit.
    Author: Heikkilä JT, Aho AJ, Yli-Urpo A, Andersson OH, Aho HJ, Happonen RP.
    Journal: Acta Orthop Scand; 1993 Dec; 64(6):678-82. PubMed ID: 8291417.
    Abstract:
    We studied osseointegration of a bioactive glass (BG) and hydroxylapatite (HA) in rabbit femur epiphyseal and metaphyseal regions. 17 BG and 24 HA cones implanted in defects through arthrotomy were analyzed. The holes for implants were drilled through distal femur joint surfaces. The cartilage wound repaired generally by fibrous tissue. Histomorphometry showed that 61, 78, and 79 percent of BG surface was covered by bone at 3, 6, and 12 weeks, respectively. The corresponding figures for HA were 47, 67, and 78 percent. Chemical bonding between bone and implants of both types was confirmed by scanning electron microscopy (SEM) and energy-dispersive x-ray analysis (EDXA). Formation of a calcium phosphate-rich layer on the surface BG implant was demonstrated by EDXA. Our results indicate that the osseointegration rate of bioactive glass does not differ from that of hydroxylapatite.
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