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  • Title: Histatin as a synergistic stimulator with epidermal growth factor of rabbit chondrocyte proliferation.
    Author: Murakami Y, Nagata H, Shizukuishi S, Nakashima K, Okawa T, Takigawa M, Tsunemitsu A.
    Journal: Biochem Biophys Res Commun; 1994 Jan 14; 198(1):274-80. PubMed ID: 8292031.
    Abstract:
    Histatin 5 dose-dependently increased DNA synthesis in rabbit costal chondrocytes in culture. The level of DNA synthesis was stimulated by histatin 5 to about 4 times that of the control. The combination of histatin 5 and epidermal growth factor (EGF) increased the DNA synthesis to about 40 times that of the control while EGF alone stimulated it 15-fold, indicating synergistic stimulation by both factors. Enzyme-linked immunosorbent assay using anti-histatin 5 demonstrated that human serum contained histatin-like substances. These findings suggest that histatins play an important role in chondrocyte proliferation, presumably as a physiological modulator of the action of EGF.
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