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  • Title: Pattern of interaction between dihydropyridine calcium antagonists and cationic amphiphilic drugs in isolated guinea-pig left atria.
    Author: Schröder F, Herzig S.
    Journal: Arzneimittelforschung; 1993 Nov; 43(11):1148-51. PubMed ID: 8292056.
    Abstract:
    The pharmacodynamic interaction between dihydropyridine calcium antagonists and several cationic amphiphilic agents with respect to their negative inotropic action has been studied in isolated guinea-pig left atria. (+/-)-Bepridil (CAS 64706-54-3), (+/-)-cis-diltiazem (CAS 33286-22-5), falipamil (CAS 77862-92-1), (+/-)-gallopamil (CAS 16662-47-2), lidocaine (CAS 6108-05-0), procainamide (CAS 614-39-1), or quinidine (CAS 50-54-4) were added at fixed concentrations. Afterwards, concentration-response curves for nifedipine (CAS 21829-25-4), the S-enantiomer niguldipine.HCl and its R-enantiomer dexniguldipine.HCl (CAS 113165-32-5), (+/-)-nimodipine (CAS 66085-59-4) (+/-)-nitrendipine (CAS 39562-70-4), or (+/-)-isradipine (CAS 75695-93-1) were obtained. In most cases, a left-ward shift in the concentration-response curve of the dihydropyridine was observed. The extent of this shift varied between dihydropyridines, and it depended on the catamphiphilic compound present. A high correlation was found between the different dihydropyridines, when comparing the extent of displacement of their concentration-response curves by the various catamphiphilic test compounds. Although quantitative differences exist between the different dihydropyridines, they are affected in potency by other compounds with a rather similar pattern. Accordingly, some general predictions about the interactions of a given dihydropyridine might be possible using limited datasets.
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