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  • Title: Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy.
    Author: Coral-Vázquez R, Arenas D, Cisneros B, Peñaloza L, Kofman S, Salamanca F, Montañez C.
    Journal: Arch Med Res; 1993; 24(1):1-6. PubMed ID: 8292871.
    Abstract:
    Forty unrelated Mexican patients with Duchenne/Becker muscular dystrophy were analyzed for intragenic DMD gene deletions, using the multiplex amplification of 15 deletion-prone exons described by Chamberlain et al. and Beggs et al. The percentage of deletions was 52.5%, and the majority of them (86.3%) were located at the hot spot deletion region which encompasses exons 44-55. This frequency is higher than that found in American and European populations. There were no correlations between deletion size, location and clinical severity.
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