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  • Title: Coactosin, a 17 kDa F-actin binding protein from Dictyostelium discoideum.
    Author: de Hostos EL, Bradtke B, Lottspeich F, Gerisch G.
    Journal: Cell Motil Cytoskeleton; 1993; 26(3):181-91. PubMed ID: 8293475.
    Abstract:
    A 17 kDa protein, designated as coactosin, has been purified from an actin-myosin complex reconstituted in vitro from a soluble fraction of Dictyostelium discoideum cells. The protein binds to F-actin in vitro without significantly altering its viscosity. Immunoblots labeled with monoclonal antibodies indicate that part of the protein is associated with the detergent-insoluble cytoskeleton. cDNA clones comprising the entire coding region of coactosin have been isolated from an expression library. The cDNA-derived amino-acid sequence reveals similarities of coactosin to the drebrins identified in neurons and to actin-binding proteins from other organisms, including yeast ABP1p, and yeast and vertebrate cofilins.
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