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  • Title: Analysis of the influence of chromosomal condensation on the activity of restriction endonucleases.
    Author: González-Tizón AM, Martínez-Lage A, Méndez J.
    Journal: Cytobios; 1993; 76(305):105-12. PubMed ID: 8293680.
    Abstract:
    The different responses of metaphase chromosomes to restriction endonuclease activity depend on the stage of chromosomal condensation. Results obtained established that this factor plays a remarkable role in obtaining high resolution banding patterns which facilitated visualization of a large number of sub-bands. It is evident that various restriction endonucleases, which are able to induce a coincident G-like banding pattern on Don cell line chromosomes, act in very different ways.
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