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  • Title: Comparative study of the carcinogenic activities of nas and some chemical carcinogens when introduced into the buccal pouch of the Syrian hamster.
    Author: Milievskaja IL, Kiseleva NS.
    Journal: Bull World Health Organ; 1976; 54(6):607-14. PubMed ID: 829414.
    Abstract:
    Studies were carried out on the carcinogenic effects of nas, 7,12-dimethylbenz-[a]anthracene (DMBA), DMBA+nas, dimethylnitrosamine (DMNA), diethylnitrosamine (DENA), and N-methyl-N-nitrosourea (MNU) when introduced into the buccal pouch of the Syrian hamster. Nas alone induced no tumours in the buccal pouch but tumours at other sites occurred in 18.8% of the treated animals, compared with 4.4% of the controls. Three of 11 hamsters treated with DMBA alone developed tumours. No tumours appeared in the buccal pouch following treatment with DMBA + nas but they developed at other sites in 6 of the 11 hamsters treated. DMNA and DENA induced no macroscopic changes in the mucous membrane of the buccal pouch. Following DMNA administration, tumours developed only in the liver; no tumours developed following the application of DENA. Tumours developed at various sites, including the buccal pouch, in 20 of the 25 hamsters treated with MNU.
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