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  • Title: [Chemotherapy of destructive pulmonary tuberculosis with antioxidants and antihypoxic agents].
    Author: Savula MM, Kravchenko NS, Poznanskiĭ AI.
    Journal: Probl Tuberk; 1993; (5):18-20. PubMed ID: 8295877.
    Abstract:
    The trial included 155 patients with destructive pulmonary tuberculosis: 60 on conventional antibacterial therapy (isoniazid, rifampicin, streptomycin), 95 on intensive chemotherapy (isoniazid, rifampicin, streptomycin, pirazinamid or ethambutol, vitamins for initial 2-3 months). 69 patients from the latter group received adjuvant antioxidants (tocopherol acetate or galascorbin) in combination with one of the antihypoxants (piracetam, calcii pangamas, piriditol). The intensive chemotherapy promoted a decrease in duration of bacterial discharge, destruction discontimation, cavernous healing, reduced incidence rates of side effects. Metabolic processes characterizing lipid peroxidation and redox improved.
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