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  • Title: [The use of fraxiparin for the prevention and treatment of thromboembolism in patients with heparin-induced thrombocytopenia].
    Author: Barkagan ZS.
    Journal: Ter Arkh; 1993; 65(10):77-82. PubMed ID: 8296242.
    Abstract:
    Seventeen patients aged 26-52 with recurrent thromboembolism of the veins and disturbances of cerebral and coronary circulation (3 and 2 cases, respectively) treated by unfractionated heparin developed thrombocytopenia in the presence of enhanced platelet aggregation. Despite heparin therapy, fresh thrombi of different sites appeared in 5 patients. A cross to fraxiparin (France) resulted in correction of thrombocytopenia, normalization of spontaneous platelet aggregation in two thirds of the patients. In 5 patients thrombocytopenia persisted. It is stated that in most cases low-molecular heparin allows continuation of antithrombotic therapy in heparin-induced thrombocytopenia. Neither transplacental passage nor hemostatic abnormalities in the newborns were recorded after administration of fraxiparin to 6 pregnant women.
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