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  • Title: Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications.
    Author: Milligan G.
    Journal: Trends Pharmacol Sci; 1993 Nov; 14(11):413-8. PubMed ID: 8296400.
    Abstract:
    Exposure of cells to agonists of receptors linked to G proteins can result in downregulation of cellular levels or redistribution of G proteins from membranes to the cytosol. Agonist-induced reductions in G protein levels have been observed for members of each of the Gs, Gi and Gq families of G proteins, are likely to be dependent upon the level of receptor expression, and are generally restricted to the G protein(s) with which the receptor interacts. The mechanisms responsible, reviewed here by Graeme Milligan, vary with cell type and include both second messenger-dependent and -independent enhanced protein degradation. Agonist-induced reduction in cellular G protein levels can provide one mechanism for the development of sustained heterologous desensitization.
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