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  • Title: Possible mode of action of nitroglycerin on heart mitochondria.
    Author: Szekeres L, Vághy P, Bor P, Csete K.
    Journal: Recent Adv Stud Cardiac Struct Metab; ; 11():495-500. PubMed ID: 829646.
    Abstract:
    Nitroglycerin has no effect on the electron transport and oxidative phosphorylation of isolated rabbit heart mitochondria at 5 X 10(-4) M and lower concentrations. However, it diminished the phosphate-induced energy-dependent potassium fluxes through the mitochondrial membrane in both directions; thus it was able to prevent the impairment of the efficiency of oxidative phosphorylation produced by increased ion transport.
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