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  • Title: Evaluation of protein kinase inhibitors in an assay system containing multiple protein kinase activities.
    Author: Li PM, Fukazawa H, Mizuno S, Uehara Y.
    Journal: Anticancer Res; 1993; 13(6A):1957-64. PubMed ID: 8297101.
    Abstract:
    Specificities of several known protein kinase inhibitors were evaluated using an assay system in which activities of protein kinase A, protein kinase C, protein tyrosine kinase and calmodulin-dependent protein kinase III were simultaneously detected. Inhibitory spectra of H-89, K252a, H-7, staurosporine, tyrphostin and herbimycin A observed in the assay system were similar to those reported in the purified protein kinase assay systems. It was also found that KN-62 selectively inhibited calmodulin-dependent protein kinase III activity. These data suggest that the assay system may be effective and practicable in evaluating specificities and screening of new protein kinase inhibitors.
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