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  • Title: Comparative study of the antitumor activity of bistramides A, D and K against a non-small cell broncho-pulmonary carcinoma.
    Author: Riou D, Roussakis C, Biard JF, Verbist JF.
    Journal: Anticancer Res; 1993; 13(6A):2331-4. PubMed ID: 8297154.
    Abstract:
    Bistramides A, D and K are substances extracted from the marine ascidian Lissoclinum bistratum Sluiter that are capable of inducing in vitro terminal differentiation (G1DT) of cells from a non-small cell broncho-pulmonary carcinoma (NSCLCN6), but present different in vitro toxicities. This study shows that only the least toxic bistramides D and K possess an antitumor activity. These two substances could be administered as a continuous treatment which would induce terminal differentiation of stem cells at their entry into the cell cycle, thereby causing their destruction.
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