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  • Title: High performance liquid chromatography of tamoxifen and metabolites in plasma and tissues.
    Author: Lim CK, Chow LC, Yuan ZX, Smith LL.
    Journal: Biomed Chromatogr; 1993; 7(6):311-4. PubMed ID: 8298286.
    Abstract:
    An isocratic reversed-phase high performance liquid chromatographic method for the determination of tamoxifen and its metabolites in plasma and tissues is described. Plasma or tissue homogenate was extracted with methanol/dimethyl sulphoxide (4:1 v/v). The supernatant after centrifugation was separated on a BDS-Hypersil column with methanol/0.5 M ammonium acetate (75:25 v/v) as the mobile phase. The recoveries of tamoxifen added to plasma and liver tissue homogenate by the extraction procedure were 102 +/- 1.6 and 98 +/- 2.4% (mean +/- SD, n = 6), respectively. The solutes were detected at 280 nm with a detection limit of 0.25 micrograms/mL for tamoxifen.
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