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  • Title: Central angiotensin converting enzyme-blockade and thirst.
    Author: Saad WA, Luiz AC, Camargo LA, Menani JV, Renzi A, Silveira JE.
    Journal: Braz J Med Biol Res; 1993 Sep; 26(9):999-1007. PubMed ID: 8298535.
    Abstract:
    1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 micrograms/microliters) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.
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