These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Methylprednisolone therapy in laser injury of the retina.
    Author: Lam TT, Takahashi K, Fu J, Tso MO.
    Journal: Graefes Arch Clin Exp Ophthalmol; 1993 Dec; 231(12):729-36. PubMed ID: 8299982.
    Abstract:
    The efficacy of methylprednisolone in argon-laser-induced retinal injury in primates was evaluated by clinical, histopathologic, and morphometric criteria. Methylprednisolone was given with a loading dose of 30 mg/kg followed by 5.4 mg/kg per hour in three different regimens: (1) starting 24 h before laser and continuing for 4 days; (2) starting immediately after laser and continuing for 4 days; and (3) starting immediately after laser and continuing for 8 h. Fundus photography, fluorescein angiography, and histologic examination showed significant beneficial effects of all three treatments compared to controls. Morphometrically, at the center of the lesion, the width of disrupted outer nuclear layer, the width of the affected RPE, and the percentage of residual photoreceptor nuclei confirmed the efficacies of treatment regimens 1 and 2, but not treatment regimen 3.
    [Abstract] [Full Text] [Related] [New Search]