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  • Title: Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis.
    Author: Hill J, Andrew PW, Mitchell TJ.
    Journal: Infect Immun; 1994 Feb; 62(2):757-8. PubMed ID: 8300240.
    Abstract:
    The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region of the toxin that affect cytolytic activity.
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