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  • Title: Short course ciprofloxacin therapy for enteric fever.
    Author: Mathai D, Kudva GC, Keystone JS, Kozarsky PE, Jesudason MV, Lalitha MK, Kaur A, Thomas M, John J, Pulimood BM.
    Journal: J Assoc Physicians India; 1993 Jul; 41(7):428-30. PubMed ID: 8300488.
    Abstract:
    A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treatment of enteric fever in 21 hospitalized patients with S.typhi (18) and S.paratyphi A(3). Median time for fever response was 3 days. All isolates were susceptible to ciprofloxacin (MIC 0.0078-0.062 mcgm/ml). The mean serum peak and trough levels were 5.4 and 1.6 mcgm/ml respectively. Stool cultures were free of Salmonellae on follow up (11-24 weeks). Two developed recurrence of paratyphoid fever, 17 days and 4 months after therapy.
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