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  • Title: Immunostimulant activity of a novel lipopeptide and its protective action against Leishmania donovani.
    Author: Puri A, Rizvi SY, Haq W, Guru PY, Kundu B, Saxena RP, Shukla R, Mathur KB, Saxena KC.
    Journal: Immunopharmacol Immunotoxicol; 1993 Nov; 15(5):539-56. PubMed ID: 8301018.
    Abstract:
    Novel lipopeptides 84/201 and 86/450 synthesized in this laboratory stimulated antibody and delayed type hypersensitivity (DTH) response to ovalbumin in guinea pigs. Lipopeptide 86/450 also stimulated antibody and DTH responses in albino mice and enhanced nonspecifically macrophage migration index (MMI), phagocytic activity and incorporation of [14C] glucosamine in peritoneal macrophages of the treated animals. Proliferative response of splenocytes from lipopeptide 86/450 treated animals was significantly higher than that from untreated controls. Peritoneal macrophages from lipopeptide 86/450 treated mice were less susceptible to Leishmania donovani promastigote invasion when co-cultured in vitro. The treated animals on challenge with L. donovani promastigote/amastigote showed 80 to 90% lower intake of infection than the control animals.
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