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  • Title: [Acute carbamazepine poisoning treated with plasmapheresis. Description of a clinical case].
    Author: Gambi D, Oggioni R, Mangani V, Librenti M, Manescalchi F, Tulli G.
    Journal: Minerva Anestesiol; 1993 Oct; 59(10):547-52. PubMed ID: 8302453.
    Abstract:
    A case of severe Carbamazepine poisoning initially misdiagnosed is reported. Treatment consisted in plasmapheresis (3.5 liters exchanged) repeated for 3 consecutive days, in conjunction with activated charcoal and advanced life support. It was obtained a rapid decay in Carbamazepine plasmatic level (with rebound phenomenon only after first treatment day) and a contemporary improvement in clinical conditions. The patient was discharged without complications after 6 days stay in ICU. Taking pharmacokinetic characteristics into account, it is suggested that plasmapheresis may be useful in this kind of poisoning.
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