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  • Title: [A trial to produce an inactivated Lassa fever vaccine].
    Author: Krasnianskiĭ VP, Potryvaeva NV, Borisevich IV, Gradoboev VN, Pashanina TP, Pshenichnov VA.
    Journal: Vopr Virusol; 1993; 38(6):276-9. PubMed ID: 8303891.
    Abstract:
    A single and double immunization of Papio hamadryas monkeys with an inactivated concentrated purified adsorbed preparation of Lassa virus in doses of 0.5-1.0 and 1.1-2.1 mg by protein, respectively, protected the animals against the development of the disease and occurrence of viremia after an intramuscular challenge with 0.4 PFU dose. Upon aerogenic infection of monkeys protection of 50% of the animals was achieved by a single immunization with the inactivated preparation in a dose 1.1 mg by protein.
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