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  • Title: [Interleukin 2 (IL-2) and its receptor (IL-2R) in healthy individuals and with various disease states].
    Author: Mazur G, Frydecka I.
    Journal: Acta Haematol Pol; 1993; 24(4):307-13. PubMed ID: 8303976.
    Abstract:
    IL-2 is a cytokine that plays a central role in immune response. It stimulates cellular as well as humoral reactivity. The effect of IL-2 depends on the interaction with its receptor. Recent reports have documented that high affinity interleukin-2 receptors consist of two distinct IL-2 binding proteins, one being alpha chain (p55) and the other being IL-2 beta chain (p75). Expression of the alpha chain or the beta chain alone allows for low affinity or intermediate affinity IL-2 binding, respectively. Alpha receptor is present on activated cells, beta chain is present on resting cells. Decreased production of IL-2 and decreased expression of IL-2 receptor (IL-2R) after stimulation was found in primary and secondary immune deficiencies. Leukemic cells in adult T cell leukemia and hairy cell leukemia express markedly large numbers of IL-2 receptors. Since IL-2 receptors are present on malignant cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T cell leukemia are treated with monoclonal antibody that binds to IL-2 receptor.
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