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  • Title: Interaction between beta-blockers and contrast media during intracoronary administration in rabbit heart.
    Author: Salbaş K, Akgün G, Pamĭr G, Gürel T.
    Journal: Acta Radiol; 1994 Jan; 35(1):70-6. PubMed ID: 8305278.
    Abstract:
    The effects of ionic, meglumine sodium diatrizoate (Urografin 76) and nonionic, iohexol contrast media were examined in the absence and presence of propranolol, a beta-blocker having nonspecific membrane stabilizing action and atenolol, a beta-blocker lacking nonspecific membrane stabilizing action on Langendorff-perfused rabbit hearts. Contrast medium, 0.7 ml, was injected into the aortic root in the absence and presence of 10(-7) and 10(-5) M beta-blocker to observe the changes in resting tension, force of contraction, rate of contraction, heart rate and PR interval. Beta-blockers and contrast media interact in affecting myocardial contractility, heart rate and atrioventricular conduction. The interaction is milder when the beta-blocker lacks membrane stabilizing activity and the contrast medium is nonionic.
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