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  • Title: The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport.
    Author: Helman CA, Barbezat GO.
    Journal: Gastroenterology; 1977 Feb; 72(2):376-9. PubMed ID: 830596.
    Abstract:
    Using a triple-lumen gut perfusion technique, the net flux of water and electrolytes in the jejunum of 5 healthy volunteers was measured before, during and after an intravenous infusion of gastric inhibitory polypeptide (GIP). The dose of GIP used (1 mug/min for 30 mins) has previously been shown to raise serum GIP levels to physiological levels achieved in normal subjects after a meal. During GIP infusion, net water Na, K, and HCO3 absorption was significantly reduced and chloride flux was switched from absorption to secretion when compared to pre- and post-GIP control periods (p less than 0.001).
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