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  • Title: Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs.
    Author: Lange W, Daskalakis M, Finke J, Dölken G.
    Journal: FEBS Lett; 1994 Jan 31; 338(2):175-8. PubMed ID: 8307177.
    Abstract:
    In chronic myelogenous leukemia (CML) the reciprocal translocation of the long arms of chromosomes results in the formation of the unique BCR/ABL fusion gene which is believed to play a crucial role in the pathogenesis of CML. Different short synthetic ribozyme constructs were compared with regard to their efficiency to cleave the BCR/ABL target RNA. In the CML cell line K562 we were able to inhibit the p210BCR/ABL synthesis by a ribozyme which was about twofold more effective than the corresponding antisense molecule.
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