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  • Title: [Clinical evaluation of S-1108 in children].
    Author: Meguro H, Mori A, Fujii R, Terashima I.
    Journal: Jpn J Antibiot; 1993 Nov; 46(11):959-66. PubMed ID: 8309072.
    Abstract:
    A new oral cephem antibiotic, S-1108, was evaluated for its clinical efficacy and safety in children. S-1108 was effective in 95% of the 59 examined cases of respiratory, middle ear, skin and urinary tract infections. S-1108 was highly effective in infections of Streptococcus pyogenes, Haemophilus influenzae and Escherichia coli, but was less effective in penicillin-resistant Streptococcus pneumoniae and Staphylococcus aureus infections. The serum half-life was 1.26 +/- 0.36 hours upon after meal administration of 4 mg/kg. No severe adverse reaction was encountered. From these data, S-1108 appears to be safe and effective in children with susceptible bacterial infections.
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