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  • Title: Effects of 2-mercaptoethanol on survival and differentiation of fetal mouse brain neurons cultured in vitro.
    Author: Ishii K, Katayama M, Hori K, Yodoi J, Nakanishi T.
    Journal: Neurosci Lett; 1993 Dec 12; 163(2):159-62. PubMed ID: 8309623.
    Abstract:
    Effects of 2-mercaptoethanol on primary cultures of fetal mouse brain neurons have been investigated. The addition of 2-mercaptoethanol to the culture medium increased 6- or 200-fold the survival rates of embryonic day-16 murine striatum neurons and day-18 cerebral cortical neurons cultured in serum-free medium, respectively, and also induced neurite outgrowth, particularly being prominent in cortical neurons. Moreover, this drug enhanced trophic activities of the conditioned medium of VR-2g or BIM cells. These findings indicate that 2-mercaptoethanol can support the viability and differentiation of fetal mouse brain neurons.
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