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  • Title: Inhibition of nitric oxide (NO) production selectively impairs learning and memory in the rat.
    Author: Estall LB, Grant SJ, Cicala GA.
    Journal: Pharmacol Biochem Behav; 1993 Dec; 46(4):959-62. PubMed ID: 8309976.
    Abstract:
    Animals administered the nitric oxide (NO) synthase inhibitor N-w-nitro-L-arginine methyl ester (NAME) for five days exhibited severe deficits in acquisition of a place-navigation learning task. The effect of NAME was selective to place-navigation learning. NAME had no effect on sensorimotor or motivational processes in a related task. These results are consistent with the view that NO participates in learning and execution of memory tasks.
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