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  • Title: [The hypoazotemic and diuretic action of lespeflan in acute kidney failure].
    Author: Guliaev VG, Ivanov IuI, Guliaeva SF.
    Journal: Urol Nefrol (Mosk); 1993; (4):32-4. PubMed ID: 8310564.
    Abstract:
    Hypoazotemic and diuretic effects of a new bioflavonoid drug lespephlan made in Russia have been tested in a dose 2 ml/kg to treat acute renal failure induced by mercury bichloride solution (a dose 2 mg/kg). The data were obtained on lespephlan ability to reduce blood levels of urea, creatinine and activate their renal elimination, to enhance diuresis, sodium clearance, glomerular filtration. Water and electrolyte release were also changeable by angiotensin aldosterone system. Mechanism of lespephlan hypoazotemic action is related to hepatic arginase inhibited activity as this enzyme plays a key role in detoxication of nitrous products urea and creatinine.
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