Title: [Primary chronic glomerulonephritis with nephrotic syndrome. Treatment with prednisone and cyclophosphamide]. Author: Knotková V, Nĕmecek K, Tarayeva IE, Krasnova TN. Journal: Vnitr Lek; 1993 Dec; 39(12):1157-63. PubMed ID: 8310664. Abstract: The authors present their long standing experience with immunosuppressive treatment of patients with nephrotic syndrome associated with primary chronic membranous, mesangioproliferative and mesangiocapillary glomerulonephritis. Of a total of 127 patients 99 were treated with prednisone and cyclophosphamide and 28 with cyclophosphamide only. Clinical remission developed in 89 patients (70%). Remissions developed independently on morphological findings and initial proteinuria, but more frequently in patients with a still normal glomerular filtration. In combined immunosuppression 77% of the treated patients developed remission, while only 48% treated with cyclophosphamide alone. 88% of the patients survive an average period of 10 years. From the investigation it is apparent that long-term and early combined immunosuppression has a favourable impact on the course of primary chronic glomerulonephritis with nephrotic syndrome.[Abstract] [Full Text] [Related] [New Search]
